Effect of Anodal Transcranial Direct Current Stimulation on Autism: A Randomized Double-Blind Crossover Trial

A, Amatachaya; N, Auvichayapat; N, Patjanasoontorn; C, Suphakunpinyo; N, Ngernyam; B, Aree-uea; K, Keeratitanont; P, Auvichayapat

Abstract:

The aim of this study was to evaluate the Childhood Autism Rating Scale (CARS), Autism Treatment Evaluation Checklist (ATEC), and Children’s Global Assessment Scale (CGAS) after anodal transcranial direct current stimulation (tDCS) in individuals with autism. Twenty patients with autism received 5 consecutive days of both sham and active tDCS stimulation (1 mA) in a randomized double-blind crossover trial over the left dorsolateral prefrontal cortex (F3) for 20 minutes in different orders. Measures of CARS, ATEC, and CGAS were administered before treatment and at 7 days posttreatment. The result showed statistical decrease in CARS score (? < 0.001). ATEC total was decreased from 67.25 to 58 (? < 0.001). CGAS was increased at 7 days posttreatment (? = 0.042). Our study suggests that anodal tDCS over the F3 may be a useful clinical tool in autism.

Patologie/Applicazioni:

• Stimolazione elettrica transcranica (TES)
• Autismo

Anno:

2014

Tipo di pubblicazione:

Articolo

Parola chiave:

stimolazione elettrica transcranica; autismo; neuromodulazione; corteccia prefrontale

Testata scientifica:

Hindawi - Behavioural Neurology

Nota:

Lo studio prende in considerazione l'effetto della stimolazione elettrica transcranica anodica (tDCS) su soggetti affetti da autismo. La stimolazione è stata eseguita per 5 sessioni giornaliere sulla corteccia prefrontale di sinistra. I soggetti sono stati valutati tramite apposite scale di misura (CARS, ATEC, CGAS). I risultati indicano un miglioramento degli indici misurati, suggerendo come la tDCS anodica eseguita sulla corteccia prefrontale possa essere utile nel trattamento dell'autismo.

DOI:

http://dx.doi.org/10.1155/2014/173073