Mechanisms of Transcranial Magnetic Stimulation Treating on Post-stroke Depression.

Duan, Xiaoqin; Yao, Gang; Liu, Zhongliang; Cui, Ranji; Yang, Wei

Abstract:

Post-stroke depression (PSD) is a neuropsychiatric affective disorder that can develop after stroke. Patients with PSD show poorer functional and recovery outcomes than patients with stroke who do not suffer from depression. The risk of suicide is also higher in patients with PSD. PSD appears to be associated with complex pathophysiological mechanisms involving both psychological and psychiatric problems that are associated with functional deficits and neurochemical changes secondary to brain damage. Transcranial magnetic stimulation (TMS) is a non-invasive way to investigate cortical excitability via magnetic stimulation of the brain. TMS is currently a valuable tool that can help us understand the pathophysiology of PSD. Although repetitive TMS (rTMS) is an effective treatment for patients with PSD, its mechanism of action remains unknown. Here, we review the known mechanisms underlying rTMS as a tool for better understanding PSD pathophysiology. It should be helpful when considering using rTMS as a therapeutic strategy for PSD.

Patologie/Applicazioni:

• Depressione
• Stimolazione Magnetica Transcranica (TMS)
• Stroke

Anno:

2018

Tipo di pubblicazione:

Articolo

Parola chiave:

Stroke; stimolazione magnetica transcranica; depressione; corteccia prefrontale

Testata scientifica:

Frontiers in human neuroscience

Nota:

Trattamento di rTMS sulla DLPFC come metodica riabilitativa per la depressione nei pazienti post-Stroke. Necessari trattamenti nuovi e più efficaci per convalidarne l'applicazione clinica facendo riferimento anche a tecniche di neuroimaging, PET ed MRi.

DOI:

10.3389/fnhum.2018.00215