Clinical review: The therapeutic use of theta-burst stimulation in mental disorders and tinnitus

T, Schwippel; PA, Schroeder; AJ, Fallgatter; C, Plewnia

Abstract:

Repetitive Transcranial Magnetic Stimulation (rTMS) is a neuromodulatory treatment intervention, which can be used to alleviate symptoms of mental disorders. Theta-burst stimulation (TBS), an advanced, patterned form of TMS, features several advantages regarding applicability, treatment duration and neuroplastic effects. This clinical review summarizes TBS studies in mental disorders and tinnitus and discusses effectivity and future directions of clinical TBS research. Following the PRISMA guidelines, the authors included 47 studies published until July 2018. Particularly in depression, evidence for the effectiveness of TBS and non-inferiority to conventional rTMS exists. Evidence for therapeutic efficacy of TBS in other mental disorders remains weak due to a large heterogeneity between studies. Rigorous reporting standards and adequately powered controlled trials are indispensable to foster validity and translation into clinical use. Nevertheless, TBS remains a promising instrument to target maladaptive brain networks and to ameliorate psychiatric symptoms.

Patologie/Applicazioni:

• Stimolazione Magnetica Transcranica (TMS)
• Tinnitus

Anno:

2019

Tipo di pubblicazione:

Articolo

Parola chiave:

stimolazione magnetica transcranica; tinnitus; Theta Burst; DLPFC

Testata scientifica:

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Nota:

La stimolazione Theta-burst (TBS), una forma avanzata e costruita di TMS, presenta numerosi vantaggi riguardo l'applicabilità, la durata del trattamento e gli effetti neuroplastici. Questa revisione clinica riassume gli studi TBS in disturbi mentali e acufene e discute l'efficacia e le direzioni future della ricerca nella TBS clinica.

DOI:

doi.org/10.1016/j.pnpbp.2019.01.014