Effect of non-invasive brain stimulation on post-stroke cognitive impairment: a meta-analysis

Zhao, J.; Meng, Q.; Qi, S.; Zhao, H.; Xia, L.

Abstract:

Background: previous studies have suggested that repetitive transcranial magnetic stimulation (rTMS) may be an effective and safe alternative treatment for post-stroke cognitive impairment (PSCI). Similarly, the application of transcranial direct current stimulation (tDCS) during stroke rehabilitation has been shown to improve cognitive function in PSCI patients. However, there have been conflicting results from some studies. Therefore, this study aims to conduct a meta-analysis to evaluate the effects of tDCS and rTMS on PSCI. Methods: the meta-analysis search for articles published from the initial availability date to 5 February 2024 in databases. The extracted study data were entered into STATA 12.0 software for statistical analysis. Results: this meta-analysis provides evidence that both rTMS and tDCS have a positive impact on general cognitive function in PSCI patients [immediate effect of rTMS: standard mean difference (SMD) = 2.58, 95% confidence interval (CI) = 1.44 to 3.71; long-term effect of rTMS: SMD = 2.33, 95% CI = 0.87–3.78; immediate effect of tDCS: SMD = 2.22, 95% CI = 1.31–3.12]. Specifically, rTMS was found to significantly improve attention, language, memory, and visuospatial functions, while it did not show a significant therapeutic effect on executive function (attention: SMD = 3.77, 95% CI = 2.30–5.24; executive function: SMD = −0.52, 95% CI = −3.17–2.12; language: SMD = 3.43, 95% CI = 1.50–5.36; memory: SMD = 3.52, 95% CI = 1.74–5.30; visuospatial function: SMD = 4.71, 95% CI = 2.61–6.80). On the other hand, tDCS was found to significantly improve executive and visuospatial functions but did not show a significant improvement in attention function and memory (attention: SMD = 0.63, 95% CI = −0.30–1.55; executive function: SMD = 2.15, 95% CI = 0.87–3.43; memory: SMD = 0.99, 95% CI = −0.81–2.80; visuospatial function: SMD = 2.64, 95% CI = 1.04–4.23). Conclusion: in conclusion, this meta-analysis demonstrates that both rTMS and tDCS are effective therapeutic techniques for improving cognitive function in PSCI. However, more large-scale studies are needed to further investigate the effects of these techniques on different cognitive domains in PSCI.

Patologie/Applicazioni:

• Stimolazione Magnetica Transcranica (TMS)
• Stimolazione elettrica transcranica (TES)
• Stroke

Anno:

2024

Tipo di pubblicazione:

Articolo

Parola chiave:

tDCS; rTMS; stimolazione elettrica transcranica; stimolazione magnetica transcranica; NIBS; deficit cognitivo; post-stroke

Testata scientifica:

Frontiers

Mese:

10

Nota:

Questo è un articolo sull'effetto della stimolazione cerebrale non invasiva sul deficit cognitivo post-ictus. Discute di studi che hanno esaminato l'efficacia della stimolazione magnetica transcranica ripetitiva (rTMS) e della stimolazione transcranica a corrente diretta (tDCS) nel trattamento del deficit cognitivo post-ictus. I risultati suggeriscono che sia la rTMS che la tDCS possono migliorare la funzione cognitiva generale nei pazienti con deficit cognitivo post-ictus. Tuttavia, la rTMS è risultata più efficace nel migliorare l'attenzione, il linguaggio, la memoria e le funzioni visuospaziali, mentre la tDCS è risultata più efficace nel migliorare le funzioni esecutive e visuospaziali. Gli autori concludono che sia la rTMS che la tDCS sono efficaci tecniche terapeutiche per migliorare la funzione cognitiva nei pazienti con deficit cognitivo post-ictus.

DOI:

10.3389/fneur.2024.1424792